Tell me, It is wrong on Infection?

Discussion in 'Biology & Genetics' started by KUMAR5, Apr 28, 2020.

  1. KUMAR5 Registered Senior Member

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    679
    Then direct Vaccine against this virus may be impossible. Other indirect routes may need to be checked.

    Horrible. Then other common targets may need to be evalued. Say eg. resisting fusion and intenalization.GL.

    As above.
     
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  3. Jeeves Valued Senior Member

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    We don't know yet. Maybe it takes longer than usual. Maybe our immune system just learns to cope without making us sicker than the usual flu. Maybe future variants won't make us sick. Maybe people will find a simple cure. Maybe it'll eventually kill us all.
    There isn't much you can do about this, except wait and take reasonable precautions.
    (And, for whatever's sake, don't listen to Trump!)
     
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  5. KUMAR5 Registered Senior Member

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    We should not be so depressed or so dependent but go on trying.

    Just study (For target at basic n common level):-



    And this one as I also quoted previously:

     
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  7. exchemist Valued Senior Member

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    Caveat: Kumar5 is quite likely to be looking for a way to introduce homeopathy into this discussion. He has a track record of starting seemingly unrelated subjects and working his way gradually round to homeopathy. He hasn't posted here for a couple of years and may be hoping everyone has forgotten last time. But I haven't: http://www.sciforums.com/threads/static-energy-electricity.159824/

    It seems to me that Covid-19, which is now cutting a swathe through India, may be an irresistible opportunity for quacks, godmen and other types of charlatan.
     
  8. KUMAR5 Registered Senior Member

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    679
    Hello. I appreciate your memory but reject your understanding. Simply, I want to better understand odd and abnormal
    happenings. Nothing homeopathy or alternative system thinking here. Pls contribute to OP.
     
  9. KUMAR5 Registered Senior Member

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    679
    Concerns related OP are well explained on this link:

    "Immunity to Covid-19 is not as clear cut as we might hope – but understanding who is immune and why will be key to finding a treatment. "
    https://www.bbc.com/future/article/20200421-will-we-ever-be-immune-to-covid-19

    Nothing is yet very clear but everything is suspected. Even though Immunological memory is not developed in this case still Antibodies
    can be developed and Innate immune system may also do something which can take care of infection for sometime subject to ist time exposure. Okay?
     
  10. exchemist Valued Senior Member

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    10,081
    That's what you said last time, too. But I'll give you the benefit of the doubt, in the hope that by raising the issue now I may make you disinclined to try it on later.

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    It is hard to contribute at the moment, as this thread seems a bit disjointed. Regarding the development of immunity to this virus, my limited understanding is that there are some key things we can't yet be sure about.

    Firstly, we don't know whether after people have been exposed once they have enough immunity to avoid a second infection. Usually one expects that but it is not always true.

    Secondly, the immune system has several ways to fight off an infection. Developing antibodies is one of them. Another is via T cells. Antibodies are proteins made in the body that bind to an antigen on the virus , preventing it from working. T cells work differently, by destroying any cells within the body that have become infected with the virus, thereby preventing it from reproducing. I have read suggestions that in this case not many antibodies are always produced, so it may be that T cells are the body's principal defence against the virus. If that should prove to be true, a vaccine can still - so I read - work, because it can "train" the T cells to recognise infection with the virus. However, looking for antibodies via a test may not be a useful way to tell whether a person has immunity or not. So this question has an impact on what test-based strategies for control of the epidemic we can use.

    So I'm afraid it is just too early to know what is going to work and how we can tell whether or not a person may be immune. This is not surprising since the virus has only been in the human population for 6 months. The rate of progress is actually astonishing. Clinical trials of vaccines are already now in progress. The Oxford one is due to be complete in August, I think, though I understand they are now worried that the control measures against the virus may make it harder for the volunteers to get themselves infected!

    Until then all we can do is stay calm, follow a balanced diet, possibly with vitamin D supplement to ensure our immune system is in good order, practise hygiene and social distancing - and read the serious media to follow progress.

    (The BBC article linked in your previous post strikes me as a very good one, by the way.)
     
    Last edited: Apr 29, 2020
  11. billvon Valued Senior Member

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    They are related, but you can create antibodies and not generate immunologic memory.
     
  12. KUMAR5 Registered Senior Member

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    Thanks for detailed explanation. To my limited knowledge, it tells me that since much antibodies are not developed and also immunological memory is not acquired by exposure, it will mean that no natural active immunity is developed. I do not understand, how T cells are not already trained and how we can develop Vaccine which can train better to T Cells? Does it also suggest we have to depend only on innate immune system and on T Cells? Then what about plasma therapy and anti viral medicines? Can we expect something from these esp those which I quoted previously?
     
  13. billvon Valued Senior Member

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    Antibodies are developed.
    That's what we don't know yet.
    Convalescent therapy - works because antibodies exist
    Viral medicines - work to some degree because they tend to inhibit viral propagation, but they do not work well on COVID-19.
     
  14. KUMAR5 Registered Senior Member

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    679
    Okay thanks. Does it suggest we do not acquire natural active immunity from the exposure of this virus? If so, it can also mean vaccine against it can also be not possible?
     
  15. billvon Valued Senior Member

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    No one knows. About all we know is that people are less likely to develop immunity against this virus. How much less? We don't know. Does that mean a vaccine based on standard methods (deactivated viruses) is less likely to work? Probably. Does that mean that another form of vaccine might work better? Perhaps. There are a lot of ways to make vaccines.
     
  16. KUMAR5 Registered Senior Member

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    Antibody test for it is not yet concluded. Yes it can only work if sufficient antibodies are developed. Then it can also mean, antibodies are developed even after first low grade infection which will make a person immune to 2nd bigger infection. Does it happen?

    Antivirals have many actions. We need to understand which will act best to control this virus and to its variants at same time for really effective control.
     
  17. KUMAR5 Registered Senior Member

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    679
    Can you tell few other ways for making vaccines then using deactivated virus?
     
  18. Jeeves Valued Senior Member

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    Genetic engineering/splicing is in the works - has been since the 1980's. I have no idea whether it's a factor in this situation. I imagine they're trying everything.
     
  19. billvon Valued Senior Member

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    18,985
    Well you can:

    Kill the virus and inject that (common.)
    Attenuate the virus by "force-evolving" it to be less virulent, then inject that
    Fragment the virus and then inject it. That will tend to create different antibodies since different antigens are exposed. They may work better or worse.
    Determine whether the virus expresses any unique proteins in-vivo. Culture them and inject them. The immune response is then targeted to cells expressing those proteins, not the virus itself.
     
  20. Write4U Valued Senior Member

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    It is now thought that viruses communicate via "quorum sensing", just like bacteria..
    If so, they can use chemical "words" to confuse the viruses so that they don't know when to become viral. The great benefit to this method is that it prevents bacteria and viruses from becoming immune, as when you kill them and only a few immune individuals survive and start a new cycle.
    Rendering viruses "deaf" to each other does not kill them directly, it prevents them from acting in concert.
    The secret social lives of viruses
    Scientists are listening in on the ways viruses communicate and cooperate. Decoding what the microbes are saying could be a boon to human health.
    https://www.nature.com/articles/d41586-019-01880-6

    Looks like we can play god to viruses and "confuse their language" (Genesis 11:7).
     
  21. KUMAR5 Registered Senior Member

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    679
    Thanks. But will all these options can still develop immunological memory or enhanced immunity against COVID?
     
  22. KUMAR5 Registered Senior Member

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    679
    Are you pointing about Disease modifying therapies by DMDs?
     
  23. billvon Valued Senior Member

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    We don't know yet.
     

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