Why People Dont Get Fat?

Carcano

Carcano

Valued Senior Member
There are many popular well known opinions on why people get fat.

But you never hear anything on the opposite condition, why some people can eat several thousand calories a day of mostly unwholesome food and NOT get fat....even while living a relatively sedentary lifestyle.

Lets hear some explanations people???
 
Genetics, exercise.

I know a person who hates exercise and has pretty good muscles. Some of these things are just random.
 
Some genes seem to lend themselves to slimness. If I could isolate them, I'd be rich. Dunno.
 
I guess I just burn it off without trying. I have a mother fucker of a metabolism. It's shitty weather here and most people are wearing normal clothes, with sleeves. I'm wearing 3/4 length pants and a cropped top. :D
 
I haven't done any formal exercise in months and I had been eating only junk food, I gained a whole lot of weight but I didn't get fat. Maybe it has something to do with fat distribution. Or just like how people get fat there are probably several reasons people stay slim.
 
CutsieMarie89 said:
I haven't done any formal exercise in months and I had been eating only junk food, I gained a whole lot of weight but I didn't get fat. Maybe it has something to do with fat distribution. Or just like how people get fat there are probably several reasons people stay slim.
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One theory has it that fat deposits in the wrong places are simply storage for toxins.

And that these can only be removed by fasting or other de-toxification disciplines.
 
MARIE! TERRIBLE! :D

If you want to remove deposits of fat permanently from your arse, I highly recommend running and a reduced calorie diet.
 
Carcano said:
There are many popular well known opinions on why people get fat.

But you never hear anything on the opposite condition, why some people can eat several thousand calories a day of mostly unwholesome food and NOT get fat....even while living a relatively sedentary lifestyle.

Lets hear some explanations people???
Click to expand...



It may have to do with enzyme MGAT2....

Nature Medicine 15, 442 - 446 (2009)

Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
Yen, C. et al.m, 2009

Animals are remarkably efficient in absorbing dietary fat and assimilating this energy-dense nutrient into the white adipose tissue (WAT) for storage. Although this metabolic efficiency may confer an advantage in times of calorie deprivation, it contributes to obesity and associated metabolic disorders when dietary fat is abundant. Here we show that the intestinal lipid synthesis enzyme acyl CoA:monoacylglycerol acyltransferase-2 (MGAT2) has a crucial role in the assimilation of dietary fat and the accretion of body fat in mice. Mice lacking MGAT2 have a normal phenotype on a low-fat diet. However, on a high-fat diet, MGAT2-deficient mice are protected against developing obesity, glucose intolerance, hypercholesterolemia and fatty livers. Caloric intake is normal in MGAT2-deficient mice, and dietary fat is absorbed fully. However, entry of dietary fat into the circulation occurs at a reduced rate. This altered kinetics of fat absorption apparently results in more partitioning of dietary fat toward energy dissipation rather than toward storage in the WAT. Thus, our studies identify MGAT2 as a key determinant of energy metabolism in response to dietary fat and suggest that the inhibition of this enzyme may prove to be a useful strategy for treating obesity and other metabolic diseases associated with excessive fat intake.​


Other sources:


MGAT2 is one of three MGAT enzymes found in the intestines of both mice and humans. Cutting MGAT activity with drugs could be another way to combat obesity, the scientists believe. Dr Robert Farese, from the University of California at San Francisco, and colleagues, reduced MGAT activity in mice by more than half by knocking out MGAT2.
Source​


The enzyme MGAT2 is found in the intestines and determines the fate of our food by regulating how it is metabolized: It either makes fat go straight to your waistline, or converts it into energy. Scientists in California have discovered that when mice are missing the gene for MGAT2, they can eat whatever they want and never have to worry about getting fat.
Source​



Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that a key enzyme involved in absorbing fat may also be a key to reducing it. The enzyme, acyl CoA: monoacylglycerol acyltransferase 2 or Mgat2 is found in the intestines and plays an important part in the uptake of dietary fat by catalyzing a critical step in making triglyceride, a kind of fat.
Source​


So, I am guessing that in fat people this enzyme is absence.. Now I wonder whether this enzyme can be synthesized, enriched and "injected" into people with obesity problem..
 
Biochemistry, first semester. You'll get your answers there. There are dozens (probably hundreds) of proteins involved with metabolism and digestion. You can't begin to look at this question without a lot of background reading.
 
Carcano said:
There are many popular well known opinions on why people get fat.

But you never hear anything on the opposite condition, why some people can eat several thousand calories a day of mostly unwholesome food and NOT get fat....even while living a relatively sedentary lifestyle.

Lets hear some explanations people???
Click to expand...

Exercise, genetics, high metabolism, tobacco and other drugs...there are a lot of potential explanations.
:m:
 
Carcano said:
Ok, but how?

The chemistry please?
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I don't think we know the chemistry. But as others have said there are a very large number of explanations.

For me personally, I fidget like none other. An NYtimes article was talking about how "fat" people tend to be more efficient in their actions and that fidgeting can burn up to 20 pounds a year. So there's yet another explanation right there.
 
Carcano said:
There are many popular well known opinions on why people get fat.

But you never hear anything on the opposite condition, why some people can eat several thousand calories a day of mostly unwholesome food and NOT get fat....even while living a relatively sedentary lifestyle.

Lets hear some explanations people???
Click to expand...

+1 for Genetics.
 
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