The fundamental premise upon which science is based is that the natural universe is a closed system, whose behavior can be predicted by theories derived logically from empirical observation of its present and past behavior.
The hypothesis that gods exist does not clash with science. Since the hypothesis stipulates specifically that they exist in a supernatural universe which is outside the boundaries of the natural universe, that hypothesis cannot be tested by science, which deals only with the natural universe. So we cannot disprove the mere
existence of gods.
However, religion doesn't stop there. It hypothesizes that those gods meddle capriciously and illogically with the behavior of the natural universe. Now this hypothesis contradicts not only science, but science's basic premise, because by definition external forces cannot affect a closed system.
The complete set of beliefs about gods that characterize all religions
attack and deny science, by claiming to have falsified its fundamental principle. After all, if a god can step off of his celestial front porch in a fit of pique and turn people into salt, raise sea level by several thousand feet in only forty days, or reanimate a corpse, then we can never rely on our empirically-based theories to predict the future behavior of the universe. Science would be virtually useless.
We cannot disprove the existence of gods. But we can test the hypothesis that the natural universe is a closed system, i.e., we can test the important part of the god thesis by establishing whether or not gods meddle with our universe. In fact we've been doing that for about 500 years, since the start of the Enlightenment. Every time the scientific method is used successfully to help us understand a natural condition or phenomenon. it's one more piece of evidence supporting that hypothesis.
Since no rigorous, respectable evidence has ever been found to cast doubt on the scientific method, the hypothesis that the natural universe is a closed system has achieved the status of a canonical theory. Of course we cannot be 100% certain that such a piece of evidence might not be discovered one day, we have not
proved that the natural universe is a closed system. We have not
proved that gods will never wake up from their slumber and start perturbing our universe. But after being tested by thousands of scientists every day for hundreds of years and never failing, we can say that the foundation of science is
true beyond a reasonable doubt.
To assert that science is wrong, that the natural universe is not a closed system, that gods stand ready to part seas, rain locusts on us and resurrect dead heroes, becomes an extraordinary assertion. The Rule of Laplace now kicks in: Extraordinary assertions must be accompanied by extraordinary evidence before we are required to treat them with respect.
In other words, we've done our homework and we are not required to prove that gods don't tamper with the workings of our universe, whether or not they exist. We have all the evidence we need to assume that gods don't exist, i.e., a natural universe that has behaved as a closed system for centuries.
The burden of proof is on the theists to provide evidence that gods not only exist, but tamper with the workings of our universe. Until such evidence is presented, we have every right to treat religion with disrespect.
So go out and enjoy yourselves.