That's very interesting. I read recently one of the inventors of the BioNTech vaccine saying he and his wife developed it having in mind the likelihood of the emergence of variants and that he was confident it would work against most of them.
Yep. There's a fair amount of intelligent guesswork to intuit which is the "key" protein to target. If it's a protein that is integral to the virus, and if removed the virus ceases to be virulent, then that's a good target, because the virus can't mutate to change it without losing its virulence. That's how the spike protein was targeted - and it looks like they guessed pretty well.
Probably it may slso take care of all variants.
Tesisting a thief to knock snd enter your door and harmvus should be a better and easy option than you let him enter your home and then do something to deal with and remove hom from home. Not do? I feel, few snti virals and vaccines can do the former. Any type of theif.
Antibodies are part of long term immunologic memory.
Yes but , should these not be secreted on need on stimulation of immunoligical memory? There should be a thought on their long term persistence in body, if express consistsnt immune or inflammatory response?
Point to be noted. Esp when even Vaccine is not claimed to be 100% effective.
You can’t be serious.
You think 1% mortality is trivial? Do you realize that’s 1 in 100? Try going to India at the moment and see what effect a 1% mortality rate is having on their society. I'm assuming you're in the USA. Are you aware SARS-CoV-2 has killed more Americans than WWII?
A respiratory virus with a 1% mortality rate makes it one of history’s greatest microbial killers. There are few examples of a virus with a higher mortality rate. The SARS-CoV-2 death toll worldwide is thought to be ~3.5 million. That’s only confirmed cases; the true total is certainly much higher (meaning that the true mortality rate might be closer to 2%). And that’s so far; this pandemic is not over.
https://www.ft.com/content/a2901ce8-5eb7-4633-b89c-cbdf5b386938
3.5 million dead makes SARS-CoV-2 one of the worst pandemics in all of recorded human history. This Wikipedia page puts it at #9. If you count only the last century it’s #3.
https://en.wikipedia.org/wiki/List_of_epidemics
A few reasons:
Yes vaccination can be good as apprant in other infections. But should we not understand very well, what a specific vaccine can give us esp when emergency approval is prefered. About short term and long term effects and side effects esp in its resistsnce caoablity of infection snd its evolutionary impacts. Many medications may be meant for cuurrent purpose but harmful in kong term. So let us try to understand these vaccines for their real need, short term outcones and long term out comes. I think, it can be done under following considerations;
It is sad that you choose to be part of the problem instead of part of the solution.
I think you miss the point of an emergency authorization. The emergency was that millions of people were dying worldwide from COVID-19; the vaccine has halted that (in areas that it is in use.) We did enough testing to know it wasn't significantly dangerous and that it worked well against COVID-19. So far it's saved around a million lives and will save far more once everyone is vaccinated. That's why we were willing to take the risk.
I don't know about you, but I would hate to find out the hard way that someone close to me was among the 1%. If I can help prevent that by getting a vaccine, then why wouldn't I?