The Pharmacology Sticky

I'm surprised meth wasn't mentioned till this page!

I would say meth and DMT are the most powerful....
 
How closely related are e and meth, btw?

Both MDMA and meth are chemically modified ephadrine I believe. In fact meth amphetamine is so easy to convert from legally available ephadrine products that
even a gcse in chemistry would not be needed. Which is probably why it's use is spreading so rapidly over traditional narcotics.
 
Both MDMA and meth are chemically modified ephadrine I believe. In fact meth amphetamine is so easy to convert from legally available ephadrine products that
even a gcse in chemistry would not be needed. Which is probably why it's use is spreading so rapidly over traditional narcotics.

The method of manufacture would be simple if basic reagents were available, but the precursors are controlled and watched, and even the precursors to the precursors are strictly controlled.

The process would be normally be way beyond any gcse student.

But to quote two old sayings:
"Where there's a will there's a way"
and
"Monkey See, Monkey do"

If anyone is in any doubt of what harm this chemical can do, do a google on its effects in Thailand.
 
Both MDMA and meth are chemically modified ephadrine I believe. In fact meth amphetamine is so easy to convert from legally available ephadrine products that
even a gcse in chemistry would not be needed. Which is probably why it's use is spreading so rapidly over traditional narcotics.
Ah, GCSE. I haven't heard of that in a while.
 
The method of manufacture would be simple if basic reagents were available, but the precursors are controlled and watched, and even the precursors to the precursors are strictly controlled.

The process would be normally be way beyond any gcse student.

But to quote two old sayings:
"Where there's a will there's a way"
and
"Monkey See, Monkey do"

If anyone is in any doubt of what harm this chemical can do, do a google on its effects in Thailand.

Seriously, if you can bake a cake you can purify ephadrine based cold medicine into crystal meth.

PS If it makes any difference I have a grade A gcse chemistry .
 
What school did you go to, St Trinians? :)

btw I've looked up Thailand myself and the situation is a bit better now than it was in 2003. The police were then operating a shoot on sight policy.
 
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I think you have to take a statistical view of this. The worst known effect of a drug is arguably not as important as its median effect.

If you ask me personally, it's caffeine. I lived through the 1960s and 1970s, I've tried drugs that I won't list on a medium monitored by government agents, protected only by a pseudonym they could hack in 8.5 seconds. None of them--none of them--caused me as much grief as caffeine.
  • Caffeine changes not just my mood but my whole personality.
  • It makes me angry, rude, loud and irritable.
  • It makes it almost impossible to sleep that night.
  • So I get up the next day not only in caffeine withdrawal, but also dead tired, needing another hit.
  • After three days of this I'm useless, dangerous and friendless.
  • On a caffeine bender--some of which have lasted for years--I have lost friends, wives, jobs, educational opportunities, weight, and quite a few other things that I won't list.
No other drug--not even ones I became addicted to--screwed up my brain and my life as badly as caffeine. I am still and will always be a recovering caffeine addict, and I'm not even very diligent about staying on the wagon.

So there's your analog to the jumping-off-the-roof or staring-into-the-sun-and-going-blind LSD anecdote. All drugs affect each of us differently. Most people don't react as I do to caffeine and most people don't do crazy stuff when they lick acid.

What's the average experience, or the median? By that measure LSD seems to be as benign as marijuana. Particularly since in a significant number of people it has the same effect as marijuana of opening up new cognitive pathways and sparking increased creativity that is not lost when the drug wears off. Or as I suspect, suppressing the logical processes that have come to dominate our lives so that the other half of our brain can have a chance to be in charge.

And don't forget the perturbation of illegality on the effect. When heroin and cocaine were legal, people of my grandparents' generation knew doctors and lawyers who were addicted to it but it didn't interfere with their work or the rest of their lives any more than caffeine addiction does to today's doctors and lawyers.

If you want to talk about the most likely effect of a drug on the average user (not someone who is already looney and just needs a push over the edge, i.e. the people most likely to want to try drugs), in my observation that would make crack and meth the worst. I admit that I don't know people who use these new alphabet-soup drugs so I can't comment on them. But the last thing I would trust is "official" reports that highlight the worst cases.
 
hmmm ok

crack really isnt that strong... in my experience weed beats it
LSD is stronger, and can blow someone away
salvia can be very strong but the trip's duration is something like 10 minutes. which is absolutely petty compared to a
5 hour DMT trip (I refer to ayahuasca) which to me has been the most intense.

but to say which drug is more powerful entails ambiguity resolution and some categori - actually it is completely dependent on your dosage

10 tabs of LSD might equal a cup of Ayahuasca (which is also completely variable ie. how much microdots in a tab, and how much bark boiled in the pot.

hmm so as I try harder to say which is more powerful it becomes obvious it is an impossible question

just remember most of what you know, outside of experience is highly saturated with propaganda
 
No other drug--not even ones I became addicted to--screwed up my brain and my life as badly as caffeine. I am still and will always be a recovering caffeine addict, and I'm not even very diligent about staying on the wagon.

That is some outrageous claim. Guess every one is different.

What is the most powerful illegal drug?

To answer you need to be specific: Stimulant or Depressant.

They can be equally powerful as far as the ability to kill. At opposite ends of spectrum would be heroin and Cocaine, but there are substitutes.

Plus it depoends on what music your listeneing to.

We have got to get it together
We have got to get it together now

Lock up the streets and houses
Because there's something in the air
 
That is some outrageous claim. Guess every one is different.
And that is exactly my point. It is outrageous. So are the claims of people dropping acid and diving into empty swimming pools. And my claim is just as real as theirs. (Well some of those are urban myths but there is a kernel of true stories beneath the mythology.) And I am just as much a one-percenter as they are. There are others. I'm trying to Google the Civil War general one of my caffeine detox therapists told me about who rode into battle swinging his sword like a berserk Visigoth instead of staying on the hill with the other high ranking officers. Turns out he was wigged out on coffee, which apparently had become widespread just in time to make the Civil War even crazier than it already was.

Everyone is different. But most people are not one-percenters. That's why they call us that.
 
Which ones?
I doubt anyone is doing atropine, as it's not a recreational drug. As for BZ, it's more of a chemical warfare agent, but does its job hallucinogenically. It's like LSD on steriods and crack (no pun intended). If it doesn't kill you, it can make you trip for months followed by some nasty psychosis.
I also doubt that anyone regularly doing crack, heroin, or meth would be a regular poster on here; they probably wouldn't have the coherency or the motivation.

.......................

Youd be surprised how many highly functional, intelligent and talented people get mixed up with drugs, espescially heroin.. personally ive never touched the stuff id probably like it too much.. lol



Nobody knows. Most street drugs are mixed for the sake of our health. People react differently to different things. 100% pure cocaine is not the same as the coke you buy from "Jose". 100% pure coke will blow your heart and spew your eyes from their sockets. Chemical engineers can even make any drug more potent. By far the most dangerous are hallucigens, I don't know about most powerful.

i did some about 90% a couple weeks ago and it was amazing.. i went to sleep after about 15 min after doing it.. along with everyone else that did it.. and yes it was definitley coke.. lol

According to the bible of drug using comedies " Fear and loathing in Las Vegas", Ether is the most powerful and depraving drug-a real low life commodity. Adrenoquine is also up there. But like I said, many drugs are not 100%. We don't even have 100%alchohol. Abusing 100% alchohol will make you pass out into a coma for 40 days, and you will wake up with temporary amnesia.

HAH LOVE this movie !! "you took too much man too much" :DDD
 
hmmm ok

crack really isnt that strong... in my experience weed beats it

crack is stronger than weed. i have never personaly tried crack, but i did used to cook it up and sell it. i used to smoke weed and sell that aswell, and one thing i know is that weed cats are not as fucked up as crack heads. all you have to do is look at the state of your average crack addict, and compare him to your regular weed smoker.


in terms of what is more powerful in addiction andhow much it messes you up, i would say crack is alot worse than weed.



peace.
 
I also doubt that anyone regularly doing crack, heroin, or meth would be a regular poster on here; they probably wouldn't have the coherency or the motivation.

dont forget they would have already sold the computer required to post long ago, to buy more crack, heroin or meth.


peace.
 
not all drug addicts are poor :) just look at some musicians.. then again theyre probably too busy partying and nailing groupies to tap away at a keyboard..
 
In terms of effects I'd say DMT, potency would be LSD and "fucks up your life" would be meth.

DMT is one of the few substances that can cause true hallucinations, not just visual distortions of what's already there.

But that's just in general, different drugs affect people in different ways.
 
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