Depp was handsome in Pirates of the Carribean. I don't really think I could elaborate on that.
Brad Pitt had an awesome body in Troy, so he's handsome (although I guess I'm going all body on that, his face is a bit average IMO).
And Ed Norton is the most attractive man I've ever seen (at least that comes to mind). In everything from Fight Club to Red Dragon to American History X, he's just been mesmerizing (although he didn't look that great in Primal Fear and The People vs. Larry Flynt, but he was young, and he played attorneys).
And I probably should add: I consider myself a heterosexual man, I just appreciate a handsome thing when I see it.
Edit: Sorry, Norton played an Alter Boy in Primal Fear, not an Attorney/Lawyer. The movie still was a heavy courtroom kinda thing though.