I recenly heard that NASA engineers said that a spacecraft with one stage to orbit is impossible. I want to prove this otherwise. What thrust-to-weight ratio would be needed, what fuel to use (how much), what material, and what shape would be needed to make this kind of spacecraft? Just think of how much cheaper space flight would be!
Not "impossible" but no sane person would try it (from Earth) as multi-stage rockets where early stage weight can be discarded once their fuel is gone are much more efficient and therefore, MUCH MUCH CHEAPER.
An alternate to rockets for the first two stages of a 3 stage system may be possible. It uses atmospheric oxygen for these first two stages. See:
http://www.sciforums.com/showpost.php?p=1652758&postcount=36
Also a few post earlier in that thread ael65 gives some good links that tell exactly how to calculate the ratio of the intital weight to " fuel exhausted" or "burn out" weight of a rocket or each stage of a multi- stage rocket and several different fuels. If seriously interested you could calculate how many times more tons of fuel would be required to launch the shuttle with only one stage.
There are better fuels than H2 and O2 in terms of what is most important (the "specific impulse") for keeping the lift off to burn out ratio as small as possible but they are more expensive and often would put hundreds of tons of toxic gas into the air near the lauch pad. The governor of Florida would not like you killing roughly 100,000 tax payers. Note that oxygen is 16 times heavier than hydrogen and burns to H2O, very non toxic, but the lift off weight of the shuttle rocket is 63% liquid oxygen! (I think this is only after the two solid fuel booster have fallen off, but they contain oxygen in chemical compound so perhaps the 63% is "at launch." These boosters get a lot of their energy from the aluminum dust they contain, which is in a rubber like solid also contining an oxygen rich chemical. I.e. Al2O3 is formed with great heat released. Al2O3 is non toxic also, Unless buried under huge pile of it.

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The shape of a single stage rocket would be essentially the same as current rockets - just a lot bigger and more expensive (at least 10 times more, I would guess.)
As far as the thrust to weight ratio required (and desired) just a little greater than unity at lift off is usually ok as the thrust remains nearly constant but the weigh is decreasing as the fuel makes exhaust gasses.
There are special time-of-flight critical cases where one needs much greater than unity for this ratio. For example, if you want to use a rocket to deliver an exploding war head near an incoming "sea skimmer" missle, which just "popped up" over the horizon and will sink your ship in about 5 seconds, you can not afford to accelerate your ship-defense counter missle at a tiny fraction of G. It had beter come off the rail (or out of the vertical launch tubes of modern Aegis ships) with an acceleration of many Gs or you are dead. Same is true, if you are trying to shoot down an incoming ICBM.
PS why is this posted here? Are you an architect? I thought "commies" were only interested in big blocks of concrete as cheap buildings, not more interesting shapes.