I personally think that science and technology in the next 100 years will be so unprofitable that industry will leave them. Why?
Because if you take into account how much is spent, how much it costs and how much is invested you get the right number, innovations, science and technology is not profitable because you invest into more complex machines, computers to solve more complex problems, unsolved mysteries and you would need more and more teams of scientists combined and after more or less 100 years in the future the industry will leave both science and technology (only weapon technology will be there healthcare and similar). And as more and more complex problems and questions arise no matter how many scientists work as hard as they can they will upper limits in understanding and explanation despite all the technology like simulations super-computer who all work together as one net of all super-computers in the world, all kinds of hyper-complex experiments on hyper-powerful machines like CERN and etc...
However, so far scientific method did the best job for today's modern living, but it's visible it does have its limits in both understanding and methodologies.
Cheers.