https://phys.org/news/2020-01-bot-beast-scientists-programmable.html Not bot, not beast: Scientists create first ever living, programmable organism: A remarkable combination of artificial intelligence (AI) and biology has produced the world's first "living robots". This week, a research team of roboticists and scientists published their recipe for making a new lifeform called xenobots from stem cells. The term "xeno" comes from the frog cells (Xenopus laevis) used to make them. One of the researchers described the creation as "neither a traditional robot nor a known species of animal", but a "new class of artifact: a living, programmable organism". Xenobots are less than 1mm long and made of 500-1000 living cells. They have various simple shapes, including some with squat "legs". They can propel themselves in linear or circular directions, join together to act collectively, and move small objects. Using their own cellular energy, they can live up to 10 days. While these "reconfigurable biomachines" could vastly improve human, animal, and environmental health, they raise legal and ethical concerns. Strange new 'creature' To make xenobots, the research team used a supercomputer to test thousands of random designs of simple living things that could perform certain tasks. The computer was programmed with an AI "evolutionary algorithm" to predict which organisms would likely display useful tasks, such as moving towards a target. After the selection of the most promising designs, the scientists attempted to replicate the virtual models with frog skin or heart cells, which were manually joined using microsurgery tools. The heart cells in these bespoke assemblies contract and relax, giving the organisms motion. more at link.... the paper: https://www.pnas.org/content/early/2020/01/07/1910837117 A scalable pipeline for designing reconfigurable organisms: Abstract Living systems are more robust, diverse, complex, and supportive of human life than any technology yet created. However, our ability to create novel lifeforms is currently limited to varying existing organisms or bioengineering organoids in vitro. Here we show a scalable pipeline for creating functional novel lifeforms: AI methods automatically design diverse candidate lifeforms in silico to perform some desired function, and transferable designs are then created using a cell-based construction toolkit to realize living systems with the predicted behaviors. Although some steps in this pipeline still require manual intervention, complete automation in future would pave the way to designing and deploying unique, bespoke living systems for a wide range of functions.