The first genetic clues to the cause of depression

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A scientific expedition into the DNA of more than 450,000 customers of gene-testing company 23andMe has uncovered the first major trove of genetic clues to the cause of depression.
The study, the largest of its kind, detected 15 regions of human genome linked to a higher risk of struggling with serious depression. The study was carried out by drug giant Pfizer as part of an alliance with 23andMe, the California company whose gene reports have been purchased by more than 1.2 million people.
So far the vast majority of efforts to locate genetic risks for depression have failed, probably because the efforts have been too small to find anything.
This gene-hunting tactic has led to important insights into diabetes, schizophrenia, and other common diseases. But depression has remained mostly untouched, until now. Previously, a study in 6,000 severely depressed Chinese women located two signals in the genome, but other surveys came up empty.