So... how much time then?
It was discovered in 1965.
It became widely used in the 80's.
To this date there is no evidence of widespread problems associated with it.
Estimates vary but it is used by approximately 250 million people worldwide.
Almost 30 years and hundreds of millions who have used it. How long does it take?
Do you have any actual and verified studies that show any harm? I bet you think you do, but you don't.
With food, it typically takes a couple of generations for effects to show up. People don't realise that the effects of food intake are cumulative, the adaptability of the body means you need to abuse it for a long time before its sufficiently damaged enough for effects to become grossly evident.
Oftentimes, even if there is an effect staring you in the face you may not realise it because its not something you are expecting based on what you think you know about the substance. Also people who do these studies often ignore the effect of confounding variables present in real life.
Sometimes, you only discover it through a fluke
http://www.cancer.gov/clinicaltrials/results/final-CARET1204People who took dietary supplements of the nutrient beta-carotene while enrolled in a large cancer prevention trial continued to have increased rates of lung cancer six years after the trial was stopped early and the supplements discontinued, long-term follow-up of trial participants has shown.
The results add to earlier evidence from this study and a second large prevention trial that, contrary to earlier expectations, not only do beta-carotene supplements not prevent lung cancer in people at high risk for the disease, they appear to increase rates of the disease, particularly among smokers.
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