However, the crucial assumption of Einstein's theory is not that there are no special frames, but that there are no special frames where the laws of physics are different. There clearly is a frame where the CMB is at rest, and so this is, in some sense, the rest frame of the Universe. But for doing any physics experiment, any other frame is as good as this one. So the only difference is that in the CMB rest frame you measure no velocity with respect to the CMB photons, but that does not imply any fundamental difference in the laws of physics...