Long Term Antibodies-Covid-19?

K

KUMAR5

Valued Senior Member
Hello,
Greetings.
:eek:ng term IgG antibodies are developed post infection or post vaccination.

Is it normal physiology or some abnormal pathology esp. in the presence of better option of
Immunological Memory available to body due to some traces of infection/virus remain existed in body for long term? I think, normally Immunological memory is developed
post infection or post vaccination but in case of Covid-19, it is long term antibodies. Why and how?

Furthur Few patients may also get Long Covid post Covid infection as per this link:

COVID-19 (coronavirus): Long-term effects
https://www.mayoclinic.org/diseases...th/coronavirus-long-term-effects/art-20490351 many patients may get Long Covid post Covid infection.

Is it possible that such long term antibodies pathological impact if possible isresponsible factor to some part of this long Covid?

Best wishes.
 
KUMAR5 said:
Is it normal physiology or some abnormal pathology esp. in the presence of better option of
Immunological Memory available to body due to some traces of infection/virus remain existed in body for long term?
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Nope. Immunologic memory is not pathological, nor does it require "traces of the infection remain." However, COVID can cause long term problems; this is often referred to as "long COVID."
 
billvon said:
Nope. Immunologic memory is not pathological, nor does it require "traces of the infection remain." However, COVID can cause long term problems; this is often referred to as "long COVID."
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Yes, Immunological memory is not pathological. I meant if Long term antibodies generated post infection or post vaccination are pathological?
 
billvon said:
They are not pathological. They are part of the normal immune response to any infection.
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But when infection is gone, say max in one month, what is the need of keeping long term antibodies for say 6 to 12 months post infection cure to body? Its role is there till infection is there say one month?
 
KUMAR5 said:
But when infection is gone, say max in one month, what is the need of keeping long term antibodies for say 6 to 12 months post infection cure to body?
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To provide better immunity to that disease for a short time.

When babies are born they get maternal antibodies via placental transfer and then through milk. This protects them until their own immune system starts to develop.
 
billvon said:
To provide better immunity to that disease for a short time.

When babies are born they get maternal antibodies via placental transfer and then through milk. This protects them until their own immune system starts to develop.
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Do you mean, it is normal life of these IgG antibodies after their secretion due to infection or vaccination? Same antibodies remain stable for long time and no new antibodues are secreted during this time?
I am asking this question because if new antibodies keep on secreting yill 6 months to 12 monts, it can also be sugfestive of that some traces of virus still remain existed in body in some dormat or accumulated state for say 6 months to 12 months, a period of existsnce of long term sntibodues?
I think in few other infection reason to existsnce of long term sntibodues is that virus remain in dirmat/latent or inactive state.
 
KUMAR5 said:
Do you mean, it is normal life of these IgG antibodies after their secretion due to infection or vaccination? Same antibodies remain stable for long time and no new antibodues are secreted during this time?
I am asking this question because if new antibodies keep on secreting yill 6 months to 12 monts, it can also be sugfestive of that some traces of virus still remain existed in body in some dormat or accumulated state for say 6 months to 12 months, a period of existsnce of long term sntibodues?
I think in few other infection reason to existsnce of long term sntibodues is that virus remain in dirmat/latent or inactive state.
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Stop pushing your nonsense all the time and listen. It suggests no such thing.

It quite obviously makes a lot of sense for an organism to retain immunity against a pathogen for a long time, because, as we see with the current virus, a disease hangs around and comes back to try to reinfect you a second time. For example, young children typically catch a lot of colds, because they do not yet have a bank of immunity against all the different versions that are flying around. As they get older, they get fewer colds, because they have come across many of them before and have some immunity to fight them off. So that is how the various immune mechanisms have evolved. Retaining immunity has survival value.

None of that implies that the viruses continue to be active - or "dormant" - inside the body. There is no basis for that. It is not how immunity works.
 
KUMAR5 said:
I am asking this question because if new antibodies keep on secreting yill 6 months to 12 monts, it can also be sugfestive of that some traces of virus still remain existed in body in some dormat or accumulated state for say 6 months to 12 months, a period of existsnce of long term sntibodues?
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No. Antibodies are primarily produced by B-lymphocytes, and they live between 1 and 2 months. Thus after an infection you might see production for 1 or 2 months. They CAN also be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. This usually occurs after a severe infection.

The antibodies themselves usually last from 2-12 months. There is some evidence that COVID antibodies stick around for about 8 months.

So you might see antibodies for 2 or 3 months after an infection, or you might see them for 40 years. All part of the normal immune response.
I think in few other infection reason to existsnce of long term sntibodues is that virus remain in dirmat/latent or inactive state.
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Why not do the research instead of just making shit up?
 
billvon said:
No. Antibodies are primarily produced by B-lymphocytes, and they live between 1 and 2 months. Thus after an infection you might see production for 1 or 2 months. They CAN also be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. This usually occurs after a severe infection.

The antibodies themselves usually last from 2-12 months. There is some evidence that COVID antibodies stick around for about 8 months.

So you might see antibodies for 2 or 3 months after an infection, or you might see them for 40 years. All part of the normal immune response.
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Yes they are. But I just want to know whether such same antibodies which are secreted due to infection or due to vaccination persist for yhis 2 months to 1 or2 months or similar new antibodies keep on secreting furing this period. Indicative half life of all tyoes of IgG antibodies is 7 to 21 days. Then how same sntibody can exist for more than this oeriod unless similar new antibodies are also keep on secreting?
https://en.wikipedia.org/wiki/Immun...n G (IgG) is a,IgG antibody has two paratopes.


hy not do the research instead of just making shit up?
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Yes I think in case of TB, EBV etc it hapoen.
 
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KUMAR5 said:
But I just want to know whether such same antibodies which are secreted due to infection or due to vaccination persist for yhis 2 months to 1 or2 months or similar new antibodies keep on secreting furing this period. Indicative half life of all tyoes of IgG antibodies is 7 to 21 days. Then how same sntibody can exist for more than this oeriod unless similar new antibodies are also keep on secreting?
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I just answered that question. Did you read my reply?
 
billvon said:
I just answered that question. Did you read my reply?
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You mentioned it:
"They CAN also be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. This usually occurs after a severe infection."

But how these will be producing when Covid infection is cured say between 15 to 30 days? Or should we take it that some traces of Covid infection in inactive state still exist in body beyond this period of remission say 15 to 30 days?
 
billvon said:
I just answered that question. Did you read my reply?
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Yes, I read carefully. But still issue is why such sntibodues are produced for prolonged period i.e. for more than 2 months? May it be ny any cells. Though some cells in body are long lived eg bone cells. If any foreign accumulation will happen in these long lived cells immune response can also be long term to remove that accumulation. Probably, it may suggest long term antibody production for this reason.
 
KUMAR5 said:
Yes, I read carefully. But still issue is why such sntibodues are produced for prolonged period i.e. for more than 2 months?
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Antibodies can be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. This usually occurs after a severe infection. This does not require "foreign accumulation" - just long lived bone marrow plasma cells.
 
billvon said:
Antibodies can be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. This usually occurs after a severe infection. This does not require "foreign accumulation" - just long lived bone marrow plasma cells.
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Yes but pls look at following quotes:
These cells originate in the bone marrow. They make proteins called antibodies which attach onto the surface of infection-causing microbes. Generally, these are Y or T shaped. Each type of antibody reacts to different microbes by sticking to molecules, called antigens, which sit on the surface of the microbe.12-Feb-2
https://www.google.com/search?q=bon...69i57.15420j0j7&client=ms-android-samsung-ga-
rev1&sourceid=chrome-mobile&ie=UTF-8
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Plasma cells, also called plasma B cells, are white blood cells that originate in the lymphoid organs as B lymphocytes and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens.
https://www.google.com/search?q=pla...msung-ga-rev1&sourceid=chrome-mobile&ie=UTF-8
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Both the above quotes suggest ythat both bone cells and plasma cells need antigens to stimulate antibody production.
Hence which antigen can be there to stimulate long term antibody production even by these cells after virus infection is cured say after 25 to 30 days?
Hence long term antibody existance post infection or post vaccination may sugfest some sntigen of virus remain still oresent/accumulated for long term even after infection is cured or after vaccination.
 
KUMAR5 said:
Both the above quotes suggest ythat both bone cells and plasma cells need antigens to stimulate antibody production.
Hence which antigen can be there to stimulate long term antibody production even by these cells after virus infection is cured say after 25 to 30 days?
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Because you need an antigen to START antibody production. You do not need an antigen to CONTINUE antibody production. That's what immunologic memory is; the memory of what the antigen was.
 
billvon said:
Because you need an antigen to START antibody production. You do not need an antigen to CONTINUE antibody production. That's what immunologic memory is; the memory of what the antigen was.
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Yes but Immunological memory will also activate on reinfection or on antigen presentation. But in case of tracing of antibodues for say 8 months is not as a result if reinfection or sntigen oresentation due to reinfection. So how this long rerm antibody can exist without reinfection or antigen presentation?
 
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