Combatting Anthrax


Registered Senior Member
Combatting Anthrax

Industry-sponsored and NASA research aimed at growing plants in space has led to a device that attacks and destroys airborne pathogens - like Anthrax.

By Dr Tony Phillips

Unseen and odourless, a cloud of Anthrax spores wafts through an office. People inside are talking, laughing ... breathing. They have no idea something is in the air. One yawn, one gasp, one happy guffaw could be deadly.

That's how bioterrorism works.

But this office has a defence: Bolted to the ceiling is a curious flat box. It's made of metal, about the size of a table-top, and it's humming softly - the sound of fans drawing airborne spores toward it and away from the people. The breeze is gentle but insistent. Eight cubic feet of air per minute flow into the box.

What lies inside is bad news for Anthrax. Swirling air forces spores through a bewildering maze of thin tubes bristling with hydroxyl (OH-) ions that attack and destroy pathogens. Some spores are buffeted against the OH-lined walls of the labyrinth. Others are caught in windy eddies where they linger, exposed to high-energy (254 nm) ultraviolet photons. Every second, one hundred billion such photons bathe the chamber - and just one is enough to destroy a spore.

"Spores that pass through the box aren't filtered, they're fried," says John Hayman, whose company, KES Science & Technology, Inc., builds and sells the device called AiroCide TiO2. "That's appealing," he notes, "for people who don't want to change an Anthrax-laden air filter." Tests show that as many as 93% of Anthrax spores that enter AiroCide TiO2 are destroyed. Survivors circulate out of the chamber where they are likely to be sucked back in again for another pass.

This extraordinary Anthrax killer is a result of NASA and industry-sponsored research aimed at building better greenhouses in space. "Greenhouses may seem to have little to do with the war against terror," says Mark Nall, the director of NASA's Space Product Development (SPD) program. "But this shows how space research, along with its direct benefits, also helps people on Earth in indirect and unexpected ways."
Hayman explains: "[Space faring] astronauts will eventually need to grow some of their own food in greenhouses. But there's a problem: the leaves of growing plants release ethylene (C2H4) - a gas that causes fruits and vegetables to mature." In the close quarters of a spacecraft (or inside an enclosed plant growth chamber), ethylene would build up and ripen greenhouse plants prematurely.

Space greenhouses needed a new technology to remove that ethylene.

In the 1990's, University of Wisconsin professor Marc Anderson and colleagues from the Wisconsin Centre for Space Automation and Robotics (WCSAR) made a crucial discovery: They found that ultra-thin layers of titanium dioxide (TiO2) exposed to ultraviolet light would efficiently convert ethylene into carbon dioxide (CO2) and water (H2O) - substances that are good for plants. Titanium dioxide itself is a harmless, non-toxic colouring agent used in many consumer products. It is a catalyst for the ethylene-destroying reaction; no TiO2 is consumed.

TiO2-based ethylene removers have since flown to space inside a pair of plant growth chambers: ASTROCULTURE™ on board NASA's space shuttle and ADVANCED ASTROCULTURE™ on the International Space Station (ISS). The devices were built by WCSAR - a NASA Commercial Space Centre at the University of Wisconsin. WCSAR is one of 17 such centres around the country sponsored by NASA's Space Product Development program to encourage the commercialisation of space by industry.

The technology worked so well that the University of Wisconsin collaborators joined forces with KES Science and Technology, Inc., to develop an ethylene scrubber for Earth. The device, called Bio-KES, works wonders in supermarkets where ethylene in the air of produce aisles reduces the shelf life of vegetables. Bio-KES was nominated as Discover Magazine's Product of the Year in 1998, and it's since been shipped across the globe for use by grocers and florists.

Moreover, Bio-KES is the parent of AiroCide TiO2.

"It was a serendipitous discovery," recalls Hayman. Tests showed that Bio-KES not only removed ethylene, but also killed airborne dust mites. Marc Anderson quickly realised why: When ultraviolet (UV) photons strike something coated by TiO2 - like the tubes inside Bio-KES - positive and negative charges appear on its surface. Those charges tear apart nearby water molecules. The OH- ion, a by-product of the reaction, disrupts organic molecules. It's deadly to dust mites, Anthrax and many other pathogens.

Technicians modified Bio-KES - adding higher-power UV lamps, for example, to give it "an extra kick," says Hayman - and AiroCide TiO2 was born.

Dean Tompkins, a colleague of Anderson's at the University of Wisconsin, is in charge of testing AiroCide TiO2. "We don't use real Anthrax," he notes. "That would be too dangerous. Instead, we experiment with one of its non-virulent cousins: Bacillus thurengiensis." During a typical experiment, Tompkins propels a cloud of approximately 1000 spores through the AiroCide chamber. Only 100 or so emerge intact.

Spores that enter AiroCide TiO2 spend at least 5 to 10 seconds in transit through the device. "That's important," adds Hayman, "because pathogens that remain inside longer are more likely to die." To slow the spores, TiO2-coated tubes within the unit are randomly arranged - there's no direct path through the machine. When air moves across the jumbled tubes, the flow becomes turbulent - forcing spores to linger where they can be attacked by OH- and illuminated by germ-killing ultraviolet light.

Such powerful tools against bio-terror indeed seem a far cry from star-trekking greenhouses, but that's how many discoveries are made: You never know what new invention might emerge - like AiroCide TiO2 - or what might be annihilated in the process - like Anthrax!

For full artical with pictures, go to

Oops... sorry, this should be in the Biology and Gentics section, guess I got over exicted from posting. Sorry about that, does anyone know how to move a thread?