Trinucleotide repeat disorders

Discussion in 'Biology & Genetics' started by Jake Arave, Nov 3, 2014.

  1. Jake Arave Ethologist Registered Senior Member

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    I've been spending the last 5-6 weeks studying CAG related disorders, namely Huntington's Disease. I've had a nagging question that I couldn't seem to find the answer to, and that question is: "What is the genomic component that is universal among all CAG-repeat disorders?" We know that they are dominantly inherited, and each offspring has a 50/50 chance to receive Huntington's Disease but what is the actual 'cause' of the disease? What makes these repetitions inheritable? Any and all insight is helpful into developing my knowledge. Thanks!
     
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  3. Jake Arave Ethologist Registered Senior Member

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    Found the information I needed.
     
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  5. GeoffP Caput gerat lupinum Valued Senior Member

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    Glad we could help.
     
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  7. James R Just this guy, you know? Staff Member

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    What will I do when I need that information?

    Please tell me, Jake, so I don't have to do the leg work.
     
  8. Jake Arave Ethologist Registered Senior Member

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    165
    Found it through various medical journals - I can't remember the exact names but it's out there if you search hard enough.
     
  9. James R Just this guy, you know? Staff Member

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    Well, this thread isn't as useful as it could have been...
     
  10. Jake Arave Ethologist Registered Senior Member

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    165
    I could answer most questions you have - without citation of course. If there is anything you need to know, just message me.
     

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