The cholesterol debate

Discussion in 'Health & Fitness' started by Syzygys, Nov 21, 2011.

  1. Syzygys As a mother, I am telling you Valued Senior Member

    More on statin and CoQ10:

    "Back in 1990s, the pharmaceutical giant, Merck, decided to add CoQ10 to a statin medication. They even went so far as to get a patent. The patent number is 4,933,165."


    So you may ask why in the world would they produce a statin with CoQ10 and the answer is quite obvious. They knew the seriousness of selling the world on statins without CoQ10.Now
    you may be thinking whatever happened to this drug. Well it never came to the marketplace. Not sure why but again they wouldn't have created this combination statin-CoQ10 drug if they were not warned of the serious consequences of promoting a statin without CoQ10."


    "In patients with high cholesterol, simvastatin therapy results in decreased serum coenzyme Q10 (CoQ10) levels.12 Several trials, including double-blind trials, have confirmed this effect of simvastatin and other HMG-CoA reductase inhibitors, such aslovastatin and pravastatin.345 Supplementation with 100 mg6 per day or 10 mg three times daily7 of CoQ10 has been shown to prevent reductions in blood levels of CoQ10 due to simvastatin. In the latter study, people taking CoQ10 along with simvastatin increased their blood CoQ10 concentration by 63%. Many doctors recommend that people taking HMG-CoA reductase inhibitor drugs such as simvastatin also supplement with approximately 100 mg CoQ10 per day, although lower amounts, such as 10–30 mg per day might conceivably be effective in preventing the decline in CoQ10 levels."
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  3. river

    I haven't read the thread , but we do know that cholesterol is important to the Brain and the body . We All know that right ?
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  5. Billy T Use Sugar Cane Alcohol car Fuel Valued Senior Member

    Most important single indicator of coronary heart disease risk is the Ratio of total cholesterol, TC, to HDL fraction. R = TC/HDL needs to be low for low risk.
    This is based on huge, multi-decade long study started in 1949. A study of 5,127 people, mostly men, half of the English town Framingham's population. The paper giving results has more than 300 citations by other researchers. The study, often called: "Population at risk" or "the Framingham study" was published here: Am. J. Medicine. 1986 vol. 80 (sup A2) by W.P.Castelli & K. Anderson. Some libraries do not retain the supplements - perhaps some good at searching can find it on the internet. I have a paper copy.

    If you have cardiac risk concerns, read this most important study. It gives effects of age, and many other factors, including blood pressure, and many graphs.
    For male 50 or older: R < 3.4 is half or less the average risk; R = 4.4 is average risk; R = 7.1 is twice the average risk.

    BTW, Total Cholesterol, TC, is almost always computed from: TC = LDL + (Tri. G. / 5) +HDL instead of measured directly.

    On 6April2009, my R was 172/ 46 = 3.739 but then total elimination of red meat and less than a dozen eggs per year, beginning in late 2009, drove R down to my all time low of only 2.86 on 1 November 2012. Perhaps I relaxed and allowed more red meat and or aging drove it back up to 3.18 on 19 May 2012 and last week (28 August 2015) R was 179/46 = 3.891 roughly normal aging effect but still less than the average risk. My blood pressure is creeping up too, but not high enough to depress it with drugs, yet. Worst ever was a recent 147 / 85. So I will begin watching it more often - may buy a home monitor.
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  7. Stoniphi obscurely fossiliferous Valued Senior Member

    I have both a home blood pressure monitor and a blood sugar test kit. I must recommend both for those with concerns along those lines.

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