Researchers pinpoint enzyme that triggers cell demise in ALS

Discussion in 'Health & Fitness' started by Plazma Inferno!, Aug 26, 2016.

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    Scientists from Harvard Medical School (HMS) have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, or ALS, a progressive and incurable neurodegenerative disorder.
    Researchers say the findings of their study may lead to new therapies to halt the progression of the uniformly fatal disease that affects more than 30,000 Americans. One such treatment is already under development for testing in humans after the current study showed it stopped nerve cell damage in mice with ALS.
    The onset of ALS, also known as Lou Gehrig’s disease, is marked by the gradual degradation and eventual death of neuronal axons, the slender projections on nerve cells that transmit signals from one cell to the next. The HMS study reveals that the aberrant behavior of an enzyme called RIPK1 damages neuronal axons by disrupting the production of myelin, the soft, gel-like substance that envelopes axons to insulate them from injury.

    http://news.harvard.edu/gazette/sto...oint-enzyme-that-triggers-cell-demise-in-als/

    Study: http://science.sciencemag.org/content/353/6299/603
     

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