Pulmonary Interstitial Fibrosis(Lung Disease)

Discussion in 'Biology & Genetics' started by plakhapate, Apr 25, 2007.

  1. plakhapate Banned Banned

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    My wife (age 51) detected above disease in October 2006.

    She gets tired after climbing even 10 steps of staircase.

    Doctor gave Steroids, which gave lot of side effects.

    Now we have slowly stopped steroid treatment.

    Allopathic doctor said there is no specific treatment and involves trial and error.

    Now we have started Ayurvedic medicine.

    Doctor says curing a disease is a slow process and may take more than one year.

    Is there any sure shot medicine and involves quick recovery.

    Pls share your experience.

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
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  3. draqon Banned Banned

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    lung transplantation

    High doses of oral corticosteroids (e.g., prednisone) are the usual treatment. Cytotoxic drugs such as cyclophosphamide and azathioprine have also been used. The response to corticosteroids is better in patients with more inflammation and less fibrosis noted on lung biopsy. Lung transplantation has been suggested for selected patients with end-stage pulmonary fibrosis. The outlook for recovery is generally poor for occupational dust diseases and idiopathic (no-known cause) interstitial pulmonary fibrosis in which the lungs progressively stiffen.
     
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  5. darksidZz Valued Senior Member

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    If you stick with Ayurvedic medicine I think you'll find its benefits outweigh those of conventional medicine. This is a type of practive that's been used for a very long time in India, they have tried many things and determined which help to relieve and prevent / cure illnesses. I myself find they usually give a great deal of energy, calmness, and help with the condition. If you continue following this there's no telling what sort of progress might be made. I certainly think this is the best choice for you.
     
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  7. plakhapate Banned Banned

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    Thanks for the reply.

    Will Oxygen Therapy be useful in this case?

    In Oxygen Therapy Oxygen Gas is used for breathing.

    Instead of this whether Oxygeneted Water is useful ?

    Pls share the experience.

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
  8. plakhapate Banned Banned

    Messages:
    249
    Recently in Australia it is found that the presence of Gasoline vapours in atmosphere provoks the Pulmonary Interstitial Fibrosis if it is in the initial stage.

    If this is true, then the gas pollution may be the reason for provoking the disease of my wife because we stayed in Andheri (Mumbai suburb) for 2 months in conjested area where vehicular pollution is very high.

    After knowing this reason , is there any medicine available for curing this disease?

    Pls share your experience.

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
  9. raviskabra Registered Senior Member

    Messages:
    5
    Pulmonary Fibrosis - Pranaayam

    Dear Mr. P.J.LAKHAPATE,

    I gone through your message, my wife (age 43 yrs) is also sufferring from Pulmonary Fibrosis. I dont want to make much comment about the medicines but I am sure if Yogas/ Pranaayaam & Various Breathing Excercises may help a lot to your wife.


    I will also welcome for any suggestions in this matter.

    Ravi Kabra.
     
  10. plakhapate Banned Banned

    Messages:
    249
    Pulmonary Interstitial Fibrosis

    Mr. Ravi Kabra,
    Pls let me know your contact details.
    See your personal email also.
    P.J.LAKHAPATE
    M-9867069587
    R-91-22-27702655
     
  11. Mosheh Thezion Registered Senior Member

    Messages:
    2,650
    IVE HEARD TALK OF SOME CHEAP DRUG BEING TESTED...

    i heard it on anther thread..

    a cure for cancer... since cancer cells use a different, oxygen starved form of metabolism.... that.. this drugs.. turns on mitocondria and stuff and thus... allows cancer cells to use oxygen, which then causes the messed up cancer cells to simply die.

    if this is true...

    the pharmicuticals will never tell you.. since they cannot make money off of it... as the drug is cheap.

    i cant remember the thread... it had links to a news story.

    -MT
     
  12. Oli Heute der Enteteich... Registered Senior Member

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    11,888
    Of course they can make money. The cheaper it is to produce the higher the profit. They'll just charge what the market will bear.
     
  13. Sputnik Banned Banned

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    888
    The only treatment with documented effect in the endstage of the disease is oxygen and lung transplantation............
     
  14. Mosheh Thezion Registered Senior Member

    Messages:
    2,650
    no... this particular drug... is so cheap... there would be no money to be made... but cancer could be cured... and it would cost the consumer about as much as an asprin.

    i wish i could remember the links or thread.

    -MT
     
  15. Mosheh Thezion Registered Senior Member

    Messages:
    2,650
  16. Oli Heute der Enteteich... Registered Senior Member

    Messages:
    11,888
    And by that logic then, no-one would make aspirin because it's too cheap to make a profit on...
    From the link:
    So there are intentions to manufacture, if the drug actually works.
     
  17. Billy T Use Sugar Cane Alcohol car Fuel Valued Senior Member

    Messages:
    23,198
    I own stock in:
    Discovery Laboratories, Inc. Quoting from their PR of about a year ago: It "is developing its proprietary surfactant technology as Surfactant Replacement Therapies (SRT) for respiratory diseases. Few or no approved non-animal derived surfactants are available. Discovery's proprietary SRT is also being developed in an aerosolized form under the name Aerosurf(TM), for neonatal respiratory disorders. Discovery is preparing to conduct Phase 2 pilot studies with Aerosurf(TM), aerosolized SRT administered through nasal continuous positive airway pressure (nCPAP). Also for premature infants, Discovery concluded a Phase 2 trial of Surfaxin for Bronchopulmonary Dysplasia (BPD), also known as Chronic Lung Disease. Discovery and announced preliminary results of a Phase 2 trial to address Acute Respiratory Distress Syndrome (ARDS) in adults, and is developing aerosol to potentially address Acute Lung Injury (ALI), cystic fibrosis and other respiratory conditions."

    DSCO, their stock symbol, is possibly the world's expert on non-cancer lung disease.
    You might want to ask them, or at least visit www.discoverylabs.com

    They have nothing on the market yet. - They would have except for some very bad luck. - of the hundreds of stability batches that were stable, one of the three designated as a "registration batch" was not stable for the full year. Stock fell dramatically and I bought some as if patient, it will do every well.

    On comments about drug being to cheap to make - that is silly you just price it at a profit level. I also own stock in BARR & TEVA, two of the largest generic drug makers. They both, especially BARR, are making patent challenges every month to try to get right to sell drugs more cheaply than current patent holder. I do not own any "big pharma" but they have bought up some of the small early stage drug developers I did own, at large profits to me.
     
    Last edited by a moderator: May 13, 2007
  18. plakhapate Banned Banned

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    249
    It is surprising to note that there is no medicine.

    Is it a rare disease?

    How many people die per year due to this disease ?

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
  19. plakhapate Banned Banned

    Messages:
    249
    Billy T,

    Can you explain what is Surfactant Replacement Therapies (SRT)?

    I am a Chemical Engr, so I will understand if you explain.

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
  20. Billy T Use Sugar Cane Alcohol car Fuel Valued Senior Member

    Messages:
    23,198
    You probably know more than me. DiscoveryLab's is a complex mix of about 8 agents (why they had some problems in meeting the year stability tests, I think) As I under stand it a "surfactant" is sort of a detergent. I am sure you know more than I do. Visit their web site, I gave it earlier. See especailly their discussion (if it is still available) of why the FDA's stability test failed. (Terrible bad luck as only one, but it was one of the three batches designated to FDA, among many dozens failed. This cost them months of investigation and has delayed comercialization by more than a year. - Millions of dollars lost, not to mention the deaths of many babies it would have saved.)
     
  21. Faerynght Registered Senior Member

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    143
    Here is a great website with all kinds of information, clinical trials, research and therapies. I hope you can find something to alleviate her symptoms and improve survival.

    http://www.pulmonaryfibrosis.org/home.htm
     
  22. Billy T Use Sugar Cane Alcohol car Fuel Valued Senior Member

    Messages:
    23,198
    At Fareynght's link you will find:

    "...Published in the March issue of the journal Chest, the research shows that more than half of the patients treated with Viagra, also known medically as Sildenafil, improved their walking distance by at least 20 percent during a standard test to measure lung function.

    "Over five million worldwide suffer from this devastating disease, so we are hopeful that this drug may prove an effective therapy for pulmonary fibrosis," said the study's principal investigator, Dr. David A. Zisman, medical director of UCLA's Interstitial Lung Disease Program and assistant professor of pulmonary and critical care medicine at the David Geffen School of Medicine at UCLA. Many patients with pulmonary fibrosis also have pulmonary hypertension, which constricts arteries and lessens blood flow to the lungs, resulting in diminished lung capacity and breathing difficulties. According to Zisman, Sildenafil may help breathing by opening or dilating blood vessels to allow more blood flow to the lungs.

    In this pilot study, 14 idiopathic pulmonary fibrosis patients initially took a standard six-minute walking test. All patients were then given oral Sildenafil therapy for three months, followed by a second walking test to gauge performance changes. Researchers noted that 57 percent of the patients improved their walking distance by 20 percent or more. The average improvement in walking distance was 49 meters (161 feet). ..."

    I am not sure, but think viagra basically increases the NO (or is it NO2 ?) in the blood. As the lungs are specaized for the exchange of gases with the blood, I would serieously look into which it is and then consider having her breadth air with a little of this "viagra gas" mixed in. Could start with low % and increase while monitoring for side effects. (Google "laughing gas" also as either NO or NO2 was extensively used by dentists years ago with only side effect being light headedness and inclination to laugh.)
     
  23. plakhapate Banned Banned

    Messages:
    249
    Now my wife has started Pranayam (3 times a day).

    This include Kapalbhati , Uddai, Bhastrika asanas.

    A tremendous improvement is seen in one month.

    Earlier she could not even walk 50 steps.

    Now she can walk to and fro two kilometer per day without much problem.

    Now climbing the stairecase is also not a big problem.

    However it is a long way to go for further improvements.

    Any suggestions for faster recovery.

    P.J.LAKHAPATE
    plakhapate@rediffmail.com
     
    Last edited: Jun 5, 2007

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