This week's eseminar at Science Online: Juan Valcárcel discusses his lab's work characterizing a novel mechanism for 3' splice site discrimination involving DEK, a chromatin-associated protein implicated in autoimmunity and cancer. The Seminar: http://biocompare.fullviewmedia.com/eseminar/science/063006_valcarcel/063006_valcarcel.html The Report: http://www.sciencemag.org/cgi/content/abstract/312/5782/1961