First, that is a compound question, and I'll need to parse it to offer my POV. ok, Universal mathematics need not be self-aware to function mathematically, but yes, there is evidence that a self-aware organism can be formed by complex mathematical chemical functions under specific local conditions This specific local phenomenon needs not be connected to a greater Universal self-awareness, but only to its implacable mathematical functions, i.e.. Universal constants. Always keep in mind that Bio-Chemistry employs a mathematical probabilistic function and unless you also want to assign intelligence to chemistry, you are already one level removed from the mathematical essence and functions of the universe. The Universe needs not be self-aware to function as it does. Nor does Chemistry.