Observation, testing and clinical application by ALL homeopaths since Hahnemann, that's how. They were actually elucidated by Constantine Hering, but Hering showed where Hahnemann had already spied them. All Hering did was to put them into succinct and cogent terms appropriate for statements of natural law. But the actual natural laws are part of the fabric of space. If you want to help us figure out the mechanism of them, good, then help and stop hindering us!