What do you mean by blackboxing? A hidden, unknown process? Artificial Selection started with the dawn of "human" and only "human" civilization and the cultivation of the Earth by choosing which grain seeds yielded the best results and the choosing of which domesticated animals that man selected to produce the best herds. Domestication of the 300+ dog breeds is strictly the result of Artificial Selection. Mendel's pea experiments. Virtually all bio-genetic experimental research in labs around the world today are done by using Artificial Selection. We now select which people we allow to live against Nature's natural forces that would otherwise kill them (Natural Selection). We keep the diseased and unfit alive and interbreed which them through our conscious choice. This is contrary to Natural Selection.