Daughters of overweight fathers may have higher cancer risk

Discussion in 'Health & Fitness' started by Plazma Inferno!, Jun 27, 2016.

  1. Plazma Inferno! Ding Ding Ding Ding Administrator

    New studies show that obese male mice, who mate with normal weight female mice, produce female pups that are overweight at birth and well into their childhood. These baby mice also develop breast tissue later than usual and have an increased rate of breast cancer.
    The researchers believe they have located evidence that obesity actually changes the microRNA (or miRNA) signature (epigenetic regulators of gene expression) in both dad’s sperm and the breast tissue of their daughters. This suggests that miRNA may carry the epigenetic information from obese dads directly to their unborn daughters. The miRNA’s help in the regulation of insulin receptor signaling, which is linked to changes in body weight as well as other molecular pathways that are associated with the development of cancer, similarly to the hypoxia signaling pathway.


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