What evidence of a Lord is there? Why would you presume someone who does not believe it necessary to submit to a Lord, would be wicked? What makes a man wicked? How would submitting to a Lord make a difference? How would anyone learn of such a Lord in the first place? Neurons are only receptors, they need something to activate them. It is not brain receptors that are turned off, but the concepts of spiritual thinking is are longer activating the neurons of those who reject the spiritual experience.