What I see the comic saying is that the girl thought lego pieces can be used in organ donation, because the older character told her that it is all in the arrangement of the pieces, and that those same pieces can become spaceships or trains. So why not arrange them for some useful and urgent purpose - like into hearts and kidneys and such.
The way I see it, the comic makes two points:
1. Concepts do not adequately translate from one field of application to another one, ie. a lego house is not exactly a house, nor can legos be used to make organs for donation. So the question is how useful is it to use toys (metaphors) in teaching/understanding concepts.
2. Based on 1., we develop notions of identity and permanence that are not necessarily realistic/adequate.