How do you find the total energy of a proton whose kinetic energy is, say, 8.5 GeV? How is the Heisenburg Uncertainty Principle taken into account?
You mention the UP so are you coming at this from a QM point of view or a relativistic one? For a relativistic point of view a proton has a rest mass of about 1GeV so a KE of 8.5GeV is going to make it quite relativistic and you have to use the usual equation \(E^{2} = (mc^{2})^{2} + |\mathbf{p}c|^{2}\). If you want a more QM based point of view you get into things like expectation values for the Hamiltonian. Then its a question of what you're viewing the proton in terms of. Is it a bound state of quarks held together by gluons (which makes it a mind-blowingly complicated non-perturbative QCD problem) or just a particle with a particular wave function?